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The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

机译:槲皮素及其与顺铂联用对恶性间皮瘤细胞体外作用的研究

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摘要

Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents.
机译:恶性间皮瘤(MM)是浆膜表面的侵袭性和致死性肿瘤,预后较差。在这项研究中,我们研究了槲皮素(QU)及其与顺铂(CIS)联合使用对SPC212和SPC111细胞系的抗增殖作用。我们的实验表明,QU以浓度和时间依赖性方式显着降低了细胞系的增殖,改变了细胞周期分布,并提高了Caspase 9(C9)和Caspase 3(C3)的水平。此外,与单独治疗药物相比,发现QU + CIS的组合更有效。

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